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Texosome-based drug delivery system for cancer therapy: from past to present

Hamideh Mahmoodzadeh Hosseini1, Raheleh Halabian1, Mohsen Amin1

  • 11 Applied Microbiology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran ; 2 Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417653861, Iran.

Cancer Biology & Medicine
|October 22, 2015
PubMed

Insights

New cancer therapies are needed due to rising incidence and drug resistance. Texosome-based delivery systems offer a promising approach for cancer immunotherapy by utilizing nanovesicles for targeted drug delivery.

Area of Science:

  • Oncology
  • Nanotechnology
  • Immunology

Background:

  • Rising global cancer rates and anti-cancer drug resistance highlight the need for novel therapeutic strategies.
  • Immune system dysfunction within the tumor microenvironment promotes cancer growth and progression.
  • Cancer immunotherapy presents a viable approach to stimulate the immune system against tumors.

Purpose of the Study:

  • To review the development of texosome-based delivery systems for cancer therapy.
  • To discuss the advantages and disadvantages of various texosome delivery strategies.
  • To explore biotechnological and mimetic approaches for enhancing texosome pharmaceutical properties.

Main Methods:

  • Review of existing literature on texosome biogenesis and function.
  • Analysis of texosome-based drug delivery systems in cancer research.
  • Evaluation of biotechnological modifications and mimetic techniques for texosomes.

Main Results:

  • Texosomes, endogenous nanovesicles from tumor cells, facilitate cell-cell communication and modify recipient cell phenotypes.
  • Texosome-based systems demonstrate potential as valuable therapeutic delivery strategies.
  • Biotechnology and mimetic techniques are employed to optimize texosome pharmaceutical behavior.

Conclusions:

  • Texosome-based delivery systems represent a promising avenue for cancer immunotherapy.
  • Further development is needed to overcome challenges and facilitate clinical application of texosome systems.
  • Understanding texosome biology is crucial for advancing their therapeutic potential.
Keywords:
Cancer therapyimmunotherapytexosome mimetictumor microenvironment

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