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Galectin-3 levels in patients with hypertrophic cardiomyopathy and its relationship with left ventricular mass index

Selcen Yakar Tülüce1, Kamil Tülüce, Zafer Çil

  • 1Department of Cardiology, İzmir Katip Çelebi University Atatürk Training and Research Hospital; İzmir-Turkey. selcenyakar@gmail.com.

Anatolian Journal of Cardiology
|October 22, 2015
PubMed

Insights

In patients with hypertrophic cardiomyopathy (HCM), Galectin-3 (Gal-3) levels were higher and correlated with left ventricular (LV) hypertrophy. However, Gal-3 did not correlate with impaired LV systolic or diastolic function.

Area of Science:

  • Cardiology
  • Biomarkers
  • Medical Imaging

Background:

  • Cardiac fibrosis contributes to adverse left ventricular (LV) remodeling and arrhythmias in hypertrophic cardiomyopathy (HCM).
  • Galectin-3 (Gal-3) is recognized as a marker for cardiac fibrosis and inflammation.

Purpose of the Study:

  • To investigate Galectin-3 (Gal-3) levels in patients with HCM compared to healthy controls.
  • To assess the relationship between Gal-3 levels and echocardiographic indices, including strain echocardiography, in HCM patients.

Main Methods:

  • A case-control study involving 40 HCM patients and 35 healthy controls.
  • Echocardiography was used to assess global LV longitudinal/circumferential strain, strain rates, peak torsion, and LV mass index (LVMI).
  • Gal-3 levels were measured in all participants.

Main Results:

  • HCM patients exhibited lower LV global longitudinal strain and strain rate compared to controls.
  • Gal-3 levels were significantly elevated in HCM patients (16.9±6.64 ng/mL) versus controls (13.21±3.42 ng/mL).
  • Gal-3 levels correlated with interventricular septum thickness and LVMI but not with LV global longitudinal strain or strain rate.

Conclusions:

  • Galectin-3 levels are elevated and correlate with the degree of left ventricular hypertrophy in patients with HCM.
  • Galectin-3 is not a reliable marker for assessing decreased LV diastolic and systolic functions in HCM patients.
Abstract

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