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Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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Intraday glucose fluctuation is common in preterm infants receiving intermittent tube feeding

Hiroshi Mizumoto1, Masahiko Kawai2, Sumie Yamashita1

  • 1Department of Pediatrics, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|October 22, 2015
PubMed

Insights

Preterm infants on tube feeding can experience significant blood glucose swings. These glucose fluctuations typically resolve as the infants approach their due date and are ready for discharge.

Area of Science:

  • Neonatology
  • Pediatric Endocrinology

Background:

  • Preterm infants may exhibit blood glucose abnormalities during enteral feeding.
  • Clinically stable preterm infants can show significant glycemic fluctuations after initiating enteral nutrition.

Purpose of the Study:

  • To investigate intraday glucose fluctuations in preterm infants receiving intermittent tube feeding.
  • To determine if these fluctuations improve as preterm infants approach term post-conceptual age.

Main Methods:

  • A case series involving 13 preterm infants (29.5 ± 2.1 post-conceptual weeks).
  • Continuous glucose monitoring (CGM) was performed at 33.5 ± 1.4 post-conceptual weeks during gastric tube feeding.
  • Infants received intermittent tube feeding every 3 hours without intravenous glucose support.

Main Results:

  • 62% of infants (8/13) displayed large intraday glucose fluctuations, including both hyperglycemia (>150 mg/dL) and hypoglycemia (<50 mg/dL).
  • Follow-up CGM in five infants between 36-38 post-conceptual weeks revealed normalized glycemic patterns without abnormal glucose levels.

Conclusions:

  • Intermittent tube feeding can cause significant intraday glucose fluctuations in preterm infants (31-35 post-conceptual weeks).
  • These glycemic fluctuations generally resolve before hospital discharge (36-38 post-conceptual weeks).
Abstract

Keywords:
continuous glucose monitoringglucose fluctuationhyperglycemiahypoglycemiapreterm infant

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