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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
Published on: December 24, 2016
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Loss of CD47 Makes Dendritic Cells See Red
Timo K van den Berg1, Robin van Bruggen1
1Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066CX, Amsterdam, the Netherlands.
Immunity
|October 22, 2015
Abstract:
Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation.

