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Published on: November 28, 2019
Tumor Microenvironment and Immunotherapy: The Whole Picture Is Better Than a Glimpse
Sarah E Church1, Jérôme Galon1
1INSERM, UMRS1138, Laboratory of Integrative Cancer Immunology, Paris, 75006, France; Université Paris Descartes, Paris 75006, France; Cordeliers Research Centre, Université Pierre et Marie Curie Paris 6, Paris 75006, France.
Abstract:
Predicting cancer patients' response to therapy is essential for curing disease and improving quality of life. Garraway and colleagues demonstrate that the frequency and number of neoantigens, non-synonymous mutations, and adaptive immune genes, but not the assessment of individual recurrent neoantigens or mutations, predicts patient responses to immunotherapy.
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