Related Experiment Video

Updated: Mar 31, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

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[The epigenome. Target for innovative therapies in head and neck carcinoma]

A Leipold1, J Hess, K Zaoui

  • 1Sektion Experimentelle und Translationale Kopf-Hals-Onkologie, Hals-Nasen-Ohrenklinik, Universitätsklinikum Heidelberg, Heidelberg, Deutschland

HNO
|October 23, 2015
PubMed
Abstract

Insights

Epigenetic aberrations drive head and neck squamous cell carcinoma (HNSCC) development and progression. Understanding these epigenetic changes offers new diagnostic biomarkers and therapeutic targets for HNSCC.

Area of Science:

  • Molecular Biology
  • Oncology
  • Epigenetics

Context:

  • Head and neck squamous cell carcinoma (HNSCC) pathogenesis involves complex genetic and epigenetic alterations.
  • Epigenomic regulation, primarily through DNA methylation and histone modifications, influences cellular plasticity in health and disease.

Purpose:

  • To explore the role of epigenetic modifications in HNSCC initiation and progression.
  • To highlight the potential of epigenetic alterations as diagnostic and prognostic biomarkers.
  • To identify epigenetic regulators as targets for novel HNSCC therapies.

Summary:

  • Epigenetic alterations are crucial in the multistage process of HNSCC development.
  • These modifications impact tumor stem cells and contribute to treatment resistance.
  • The stability of epigenetic marks makes them valuable biomarkers, while their reversibility offers therapeutic opportunities.

Impact:

  • Advances understanding of HNSCC pathogenesis.
  • Identifies potential biomarkers for early detection and prognosis.
  • Paves the way for developing targeted epigenetic therapies for HNSCC.

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