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Filtration

Filtration

Filtration is a physical separation process that involves passing a suspension through a porous medium to separate solids from fluids. During filtration, solids collect on the porous medium while liquids, also collectively known as the filtrate, pass through. The filtration medium is selected based on the filtration purpose, quantity, and nature of the precipitate. The general criteria for a suitable filtering medium are that it is inert, mechanically strong, nonabsorbent toward dissolved...

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Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing

Published on: February 13, 2016

Dynamic cross-flow filtration: enhanced continuous small-scale solid-liquid separation.

Johannes Gursch¹, Roland Hohl¹, Diana Dujmovic¹

¹a Research Center Pharmaceutical Engineering Graz , Graz , Austria .

Drug Development and Industrial Pharmacy

|October 23, 2015

Summary

This summary is machine-generated.

This study enhanced small-scale dynamic filtration (SFD) by testing vacuum-enhanced and pulsating modes. These modes significantly increased permeate flow and concentration factors, improving continuous production efficiency.

Keywords:

Continuous manufacturing cross-flow filtration membrane filtration pharmaceutical production small-scale

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Published on: December 12, 2019

Area of Science:

Chemical Engineering
Separation Processes
Filtration Technology

Background:

Previous research characterized basic mechanisms of small-scale dynamic filtration (SFD).
The current study focuses on enhancing SFD production performance.

Purpose of the Study:

To improve SFD performance for increased permeate flow and concentration factors (CF).
To maintain fully continuous production while optimizing operational modes.

Main Methods:

Testing various operational modes, including vacuum-enhanced and pulsating operations.
Comparing performance against the standard open-operation mode for filtration.

Main Results:

Vacuum-enhanced and pulsating modes significantly outperformed the open-operation mode.
For lactose, CF increased from 1.7 (open mode) to 7.6 (pulsating mode).
Improved filtration performance and process flexibility were observed.

Conclusions:

Vacuum-enhanced operation is most promising for industrial integration.
The tested strategies enable rapid response to fluctuating feed conditions.
Enhanced SFD operation leads to effective and efficient continuous small-scale filtration.