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Updated: Mar 31, 2026

High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids
Published on: June 14, 2021
[Relationship between Polymorphisms and the Efficacy of Cetuximab]
Yuka Inoue1, Shoichi Hazama, Ryoichi Tsunedomi
1Dept. of Digestive Surgery and Surgical Oncology(SurgeryⅡ), Yamaguchi University Graduate School of Medicine.
Fragment c gamma receptor (FcgR) polymorphisms may influence outcomes for metastatic colorectal cancer patients treated with cetuximab. Specific FcgR haplotypes and diplotypes were linked to lower response rates, warranting further investigation.
Area of Science:
- Oncology
- Pharmacogenomics
- Cancer Immunology
Background:
- Cetuximab is effective for metastatic colorectal cancer (mCRC).
- Cetuximab efficacy is linked to antibody-dependent cell-mediated cytotoxicity (ADCC) via fragment c gamma receptors (FcgR).
- KRAS mutations predict poor response, necessitating additional biomarkers for patient selection.
Purpose of the Study:
- To investigate the association between FcgR polymorphisms and treatment outcomes in mCRC patients receiving cetuximab.
- To identify potential biomarkers for predicting cetuximab response.
Main Methods:
- Analysis of 57 mCRC patients treated with cetuximab.
- Evaluation of the relationship between FcgR polymorphisms and response rate (RR), progression-free survival (PFS), and overall survival (OS).
Main Results:
- Overall, FcgR polymorphisms did not show a significant relationship with RR, PFS, or OS.
- A specific haplotype containing 131H and 158V alleles was associated with a lower RR (p=0.018).
- Diplotypes with 131H and 158V alleles demonstrated significantly lower RR compared to other diplotypes (p=0.038).
Conclusions:
- FcgR polymorphisms might influence outcomes in mCRC patients treated with cetuximab and FOLFIRI.
- These findings suggest a potential role for FcgR polymorphisms in predicting cetuximab efficacy.
- Further research is required to confirm the controversial relationship between FcgR polymorphisms and cetuximab effectiveness.
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