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Cytomegalovirus as an Insidious Pathogen Causing Duodenitis
Hideharu Hagiya1, Masaya Iwamuro, Takehiro Tanaka
1Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.e_dai_for_all@hotmail.com.
Acta Medica Okayama
|October 23, 2015
Summary
Cytomegalovirus (CMV) duodenitis is a rare condition that can occur in immunocompromised patients. Diagnosis requires biopsy, even with non-specific endoscopic findings, to confirm CMV gastrointestinal infection.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pathology
Background:
- Rheumatoid arthritis patients on long-term methotrexate therapy are at risk for opportunistic infections.
- Cytomegalovirus (CMV) can affect the upper gastrointestinal tract, including the duodenum.
Observation:
- A 60-year-old woman presented with epigastric discomfort.
- Initial tests revealed cytomegalovirus (CMV) antigenemia.
- Esophagogastroduodenoscopy showed non-specific duodenal mucosal lesions.
Findings:
- Pathological examination of duodenal biopsies confirmed cytomegalovirus (CMV) duodenitis.
- CMV duodenitis is infrequently reported, with limited clinical and pathological data.
Implications:
- CMV infection should be considered in the differential diagnosis of gastrointestinal symptoms in high-risk patients.
- Biopsy is crucial for diagnosing CMV gastrointestinal infections, irrespective of endoscopic findings.
- Early diagnosis and treatment of CMV duodenitis can prevent complications in immunocompromised individuals.
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