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Related Experiment Video

Updated: Mar 31, 2026

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Benign soft tissue lesions that may mimic malignancy.

Jessica A Forcucci1, Evelyn T Bruner1, Michael Timothy Smith1

  • 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 171 Ashley Ave MSC 908, Charleston, South Carolina 29425.

Seminars in Diagnostic Pathology
|October 23, 2015
PubMed
Summary

Pathologists face challenges distinguishing benign soft tissue lesions from malignant tumors. This review details common pseudosarcomas, emphasizing diagnostic pitfalls and the need for multidisciplinary correlation.

Keywords:
Malignancy mimicPseudoneoplasticPseudosarcomaSoft tissue

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Area of Science:

  • Pathology
  • Oncology
  • Radiology

Background:

  • Soft tissue lesions mimicking malignancy (pseudosarcomas) present diagnostic difficulties.
  • Features like rapid growth and cellularity can be misleading, appearing in benign conditions.

Observation:

  • This review focuses on specific repair reactions and benign tumors.
  • Examples include nodular fasciitis, lipomas, and myxomas.

Findings:

  • Benign lesions can exhibit malignant-like features, leading to misdiagnosis.
  • Understanding these pseudoneoplastic lesions is crucial.

Implications:

  • Accurate diagnosis requires integrating clinical, pathological, and radiological data.
  • Correlative approaches minimize misdiagnosis of soft tissue tumors.