Related Experiment Video
Updated: Mar 31, 2026
08:32
Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice
Published on: March 10, 2017
10.7K
FGF23 in Acute and Chronic Illness
Christian Schnedl1, Astrid Fahrleitner-Pammer2, Peter Pietschmann3
1Division of Vascular and Interventional Radiology, Department of Radiology, Medical University of Graz, 8036 Graz, Austria.
Disease Markers
|October 23, 2015
Summary
Fibroblast growth factor 23 (FGF23) is a bone hormone rising in chronic kidney disease and acute illness, indicating higher patient risk. This review explores FGF23 as a disease biomarker and discusses interventions.
Area of Science:
- Endocrinology
- Nephrology
- Biomarker Research
Background:
- Fibroblast growth factor 23 (FGF23) is a bone-derived hormone.
- FGF23 elevation is linked to increased morbidity and mortality in chronic kidney disease.
- Emerging evidence indicates FGF23 is also elevated in acute illness.
Purpose of the Study:
- To review the role of FGF23 as a disease biomarker.
- To discuss interventional strategies targeting FGF23.
- To outline future research directions.
Main Methods:
- Literature review of existing studies on FGF23.
- Analysis of FGF23's association with chronic and acute diseases.
- Synthesis of data on FGF23 interventional strategies.
Main Results:
- FGF23 rises early in chronic kidney disease, predicting poor outcomes.
- FGF23 is elevated in various acute disease states.
- Interventional strategies targeting FGF23 show potential.
Conclusions:
- FGF23 is a promising biomarker for identifying high-risk patients in both chronic and acute settings.
- Further research is needed to fully elucidate FGF23's role and optimize interventions.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
957
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
957
01:29Acute Respiratory Failure-V
643
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
643
01:27Acute Pancreatitis I: Introduction
1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
01:29Acute Kidney Injury III: Clinical Manifestations
1.4K
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.4K
01:30Acute Pancreatitis II: Clinical Manifestations and Management
1.1K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.1K
01:29Acute Kidney Injury II: Pathophysiology
1.9K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.9K