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Cancer Microenvironment and Endoplasmic Reticulum Stress Response

Claudia Giampietri1, Simonetta Petrungaro1, Silvia Conti1

  • 1Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Section of Histology and Medical Embryology, Sapienza University of Rome, 00161 Rome, Italy.

Mediators of Inflammation
|October 23, 2015
PubMed
Summary

Tumor cells activate the unfolded protein response (UPR) under stress, aiding their survival and proliferation. This review details UPR mechanisms promoting cancer growth, focusing on prostate cancer and melanoma.

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