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Onychomycosis treated with a dilute povidone-iodine/dimethyl sulfoxide preparation

Kara Capriotti1, Joseph A Capriotti2

  • 1ALC Therapeutics, LLC, Springhouse, PA, USA ; Bryn Mawr Skin and Cancer Institute, Rosemont, PA, USA.

International Medical Case Reports Journal
|October 23, 2015
PubMed
Abstract

Insights

A novel topical povidone-iodine/dimethyl sulfoxide formulation effectively treated severe, treatment-resistant onychomycosis. This combination therapy shows promise for fungal nail infections.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmaceutical Science

Background:

  • Povidone-iodine (PVP-I) 10% is a safe topical antiseptic with no known fungal resistance.
  • A low-dose 1% PVP-I in dimethyl sulfoxide (DMSO) formulation is used clinically.
  • This case report details its use in a severe, refractory onychomycosis case.

Observation:

  • A 49-year-old female patient presented with severe onychomycosis.
  • Previous treatments including OTC, topical, and oral therapies were ineffective.

Findings:

  • The topical povidone-iodine/DMSO combination demonstrated high efficacy.
  • Significant alleviation of onychomycosis signs and symptoms was observed.

Implications:

  • This novel PVP-I/DMSO combination warrants further investigation.
  • Randomized controlled trials are needed to confirm clinical utility for onychomycosis treatment.
Keywords:
fungusnailonychomycosispovidone-iodine

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