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Premature Termination Codons Are Recognized in the Nucleus in A Reading-Frame Dependent Manner

Min Shi1, Heng Zhang1, Lantian Wang1

  • 1State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Cell Discovery
|October 23, 2015
PubMed
Summary

Premature termination codons (PTCs) in messenger RNAs (mRNAs) trigger nuclear retention, not degradation. Ribosomes in the nucleus detect PTCs, recruiting Upf1 protein to hold faulty mRNAs, ensuring protein production fidelity.

Keywords:
Nuclear retentionPremature termination codons (PTCs)Upf1nuclear frame reading

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