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Related Experiment Videos

Verapamil in affective disorders: a controlled, double-blind study.

C Höschl1, J Kozený

  • 1Department of Psychiatry, Medical Faculty of Hygiene, Charles University, Prague, Czechoslovakia.

Biological Psychiatry
|January 15, 1989
PubMed
Summary

This study found that amitriptyline and state-adjusted treatment (SAT) were more effective than verapamil or placebo for depression. Verapamil showed comparable results to neuroleptics in treating mania without significant side effects.

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Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Depression and mania are significant psychiatric conditions requiring effective treatment.
  • The efficacy of verapamil, a calcium channel blocker, in psychiatric disorders is under investigation.
  • Comparative studies are crucial for understanding treatment options for mood disorders.

Purpose of the Study:

  • To compare the efficacy of verapamil, amitriptyline, placebo, and state-adjusted treatment (SAT) in depressed inpatients.
  • To evaluate verapamil's effectiveness in treating manic inpatients compared to standard treatments.

Main Methods:

  • Eighty-six depressed inpatients were randomized into four treatment groups: verapamil, amitriptyline, placebo, and SAT.
  • Psychopathology was assessed using the Hamilton Rating Scale for Depression, Zung self-rating scale, 100-mm analog scale, and clinical impression.

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  • Twelve manic inpatients received verapamil, 24 received neuroleptics, and 11 received both neuroleptics and lithium carbonate, with psychopathology assessed by the Brief Psychiatric Rating Scale (BPRS).

    • Main Results:

    • Amitriptyline and SAT demonstrated superior efficacy over verapamil and placebo in treating depression.
    • No significant difference was found between verapamil and placebo, or between SAT and amitriptyline.
    • In manic patients, verapamil showed comparable psychopathology reduction to neuroleptics, with borderline statistical significance favoring verapamil.
    • Verapamil was well-tolerated and did not cause sedative or cataleptic effects.

    Conclusions:

    • Amitriptyline and SAT are effective treatments for depression.
    • Verapamil may be a viable alternative for treating mania, offering a favorable side-effect profile compared to neuroleptics.