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Updated: Mar 31, 2026

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
Reverse Pseudohyperkalemia: An Important Clinical Entity in Chronic Lymphocytic Leukemia
Sahar Mansoor1, Noa G Holtzman1, Ashkan Emadi1
1University of Maryland School of Medicine, Marlene & Stewart Greenebaum Cancer Center, Baltimore, MD 21201, USA.
Abstract:
Hyperkalemia is a potentially lethal electrolyte derangement commonly seen in patients with hematologic neoplasms with or without renal failure. Pseudohyperkalemia and reverse pseudohyperkalemia also can be seen in this patient population and early recognition and diagnosis of these conditions are vital. Here, we report a case of reverse pseudohyperkalemia in a patient with chronic lymphocytic leukemia (CLL) and provide recommendations regarding diagnostic and therapeutic strategies for management of such patients. Further, we discuss the pathogenesis of this condition and its potential role as a surrogate of favorable prognostic features in patients with CLL.
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