Related Experiment Video
Updated: Mar 31, 2026
09:14
Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
2.9K
Systemic Sarcoidosis Presenting with Headache and Stroke-Like Episodes
J Campbell1, R Kee1, D Bhattacharya2
1Department of Neurology, Royal Victoria Hospital, Belfast BT12 6BA, UK.
Case Reports in Immunology
|October 23, 2015
Summary
Sarcoidosis can rarely present as neurological symptoms, including stroke, in young adults. Early diagnosis and corticosteroid treatment led to a positive outcome in this case.
Area of Science:
- Neurology
- Immunology
- Radiology
Background:
- Sarcoidosis is a multisystem granulomatous disease.
- Neurological involvement is an uncommon presentation.
- Cerebrovascular events are rare initial symptoms.
Purpose of the Study:
- To report a case of sarcoidosis presenting with stroke-like symptoms.
- To emphasize sarcoidosis as a differential diagnosis in young stroke patients.
- To highlight the importance of early diagnosis and treatment.
Main Methods:
- Case report of a 26-year-old male with neurological symptoms.
- Brain MRI revealed inflammatory white matter lesions and microhemorrhages.
- CSF analysis showed elevated pressure and inflammation.
- CT scans identified widespread lymphadenopathy.
- Axillary lymph node biopsy confirmed noncaseating granulomata.
Main Results:
- Patient presented with headache, hemiparesis, and numbness.
- Neuroimaging demonstrated diffuse vasculopathy and ischemic focus.
- Systemic sarcoidosis was diagnosed based on lymph node biopsy.
- Cerebrospinal fluid analysis indicated neurological inflammation.
- The patient showed significant improvement with corticosteroid therapy.
Conclusions:
- Sarcoidosis should be considered in young patients presenting with stroke.
- Neurological sarcoidosis can manifest as cerebrovascular disease.
- Prompt treatment with corticosteroids is effective for neurological sarcoidosis.
Related Concept Videos
01:24Chronic Kidney Disease II: Clinical Manifestations
957
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
957
01:23Rheumatic Heart Disease I: Introduction
868
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
868
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
520
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
520
01:25Endocarditis II: Clinical Features of Infective Endocarditis
794
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
794
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
1.0K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.0K
01:18Viral Meningitis
96
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
96