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Four new low molecular weight hydrogelators (LMWGs) were synthesized and tested for hydrogel formation triggered by pH changes. Fmoc-L-Tyr-D-Oxd-OH 1 demonstrated excellent gelation, forming strong, transparent, and viscoelastic hydrogels with good thermal stability.

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science

Background:

  • Low molecular weight hydrogelators (LMWGs) are crucial for developing advanced functional materials.
  • Controlling hydrogel properties through stimuli-responsive triggers like pH is an active research area.

Purpose of the Study:

  • To synthesize and characterize novel LMWGs capable of forming hydrogels.
  • To investigate the gelation behavior and properties of these LMWGs, particularly their response to pH variations.

Main Methods:

  • Synthesis of four new LMWGs on a multigram scale.
  • Characterization of hydrogel properties including melting points (Tgel), transparency, gelation time, and viscoelasticity using techniques like UV-Vis spectroscopy and rheology.
  • ECD analysis was also performed.

Main Results:

  • Fmoc-L-Tyr-D-Oxd-OH 1 was identified as an excellent gelator, forming strong, transparent, and viscoelastic hydrogels upon pH variation.
  • The resulting hydrogels exhibited high transparency (up to 25.6% transmittance at 600 nm) and predominantly elastic behavior (G' > G'').
  • Rheological temperature sweep revealed good thermal stability, with G' remaining constant up to approximately 65 °C.

Conclusions:

  • pH-triggered hydrogels derived from Fmoc-L-Tyr-D-Oxd-OH 1 show promising properties for various applications.
  • The synthesized LMWGs offer tunable characteristics for advanced material design.