Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nucleophilic Aromatic Substitution: Elimination–Addition01:11

Nucleophilic Aromatic Substitution: Elimination–Addition

5.5K
Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
5.5K
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)01:30

Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)

5.2K
Nucleophilic substitution in aromatic compounds is feasible in substrates bearing strong electron-withdrawing substituents positioned ortho or para to the leaving group. The reaction proceeds via two steps: the addition of the nucleophile and the elimination of the leaving group.
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between...
5.2K
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene01:15

Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene

12.9K
Chlorination and bromination are important classes of electrophilic aromatic substitutions, where benzene reacts with chlorine or bromine in the presence of a Lewis acid catalyst to give halogenated substitution products. A Lewis acid such as aluminium chloride or ferric chloride catalyzes the chlorination, and ferric bromide catalyzes the bromination reactions. During the bromination of alkenes, bromine polarizes and becomes electrophilic. However, in the bromination of benzene, the bromine...
12.9K
Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride01:26

Radical Substitution: Hydrogenolysis of Alkyl Halides with Tributyltin Hydride

2.3K
Radical substitution reactions can be used to remove functional groups from molecules. The hydrogenolysis of alkyl halides is one such reaction, where the weak Sn–H bond in tributyltin hydride reacts with alkyl halides to form alkanes. Here, the reagent Bu3SnH yields tributyltin halide as a byproduct.
The bonds formed in this reaction are stronger than the bonds broken, making it energetically favorable. The reaction follows a radical chain mechanism similar to radical halogenation reactions,...
2.3K
Predicting Products: Substitution vs. Elimination02:52

Predicting Products: Substitution vs. Elimination

15.1K
When a nucleophile and an alkyl halide react, nucleophilic substitution and β-elimination reactions compete to generate products.
The following factors can influence the mechanisms competing against each other:
15.1K
Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

9.1K
Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the Phytochemical Constituents, Anti-Inflammatory, and Neuropharmacological Activities of Podocarpus neriifolius Leaves Through FT-IR, GC-MS, Experimental Studies, Molecular Docking, and Molecular Dynamics Simulations.

Pharmacology research & perspectives·2026
Same author

Neuropharmacological, Analgesic, and Anti-Inflammatory Activities of <i>Pothos scandens</i> Acetone Extract With GC-MS-Based Phytochemical Profiling.

Biochemistry research international·2026
Same author

Pharmacological evaluation of Adenostemma lavenia acetone extract in Swiss Albino mice: Analgesic, anti-inflammatory, and thrombolytic insights from in vivo, in vitro, density functional theory, and molecular docking studies.

Animal models and experimental medicine·2026
Same author

Mushrooms as potent autophagy modulators in cancer therapy: Current evidence and therapeutic prospects.

Cancer pathogenesis and therapy·2026
Same author

Deciphering the Antioxidant and Neuropharmacological Effects of Methanolic Extract of <i>Artocarpus chama</i> Leaves and Its n-Hexane and Ethyl Acetate Fractions: GC-MS Analysis, Experimental, and In Silico Investigations.

Food science & nutrition·2025
Same author

Comprehensive Evaluation of Methanolic Fruits Extract of Jatropha gossypifolia L.: Neuropharmacological, Cytotoxic, Anthelmintic, GC-MS Profiling, and Molecular Docking Studies.

Pharmacology research & perspectives·2025

Related Experiment Video

Updated: Mar 31, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

12.3K

A Novel Byte-Substitution Architecture for the AES Cryptosystem.

Fakir Sharif Hossain1, Md Liakot Ali2

  • 1Department of Electrical and Electronic Engineering, International Islamic University Chittagong, Chittagong, Bangladesh.

Plos One
|October 23, 2015
PubMed
Summary

This study introduces a novel S-box architecture for the Advanced Encryption Standard (AES), significantly improving speed, area, and power efficiency. The new design offers superior performance compared to existing AES S-box techniques.

More Related Videos

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
06:47

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development

Published on: August 25, 2023

1.9K
Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.2K

Related Experiment Videos

Last Updated: Mar 31, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

12.3K
Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development
06:47

Author Spotlight: A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development

Published on: August 25, 2023

1.9K
Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.2K

Area of Science:

  • Cryptography
  • Digital Hardware Design
  • Computer Engineering

Background:

  • The performance of the Advanced Encryption Standard (AES) is critically dependent on its S-box component.
  • Existing S-box designs present trade-offs between speed, area, and power consumption.
  • Optimizing the S-box is crucial for efficient AES implementations.

Purpose of the Study:

  • To propose a new S-box architecture for AES that is ultra-low power, robustly parallel, and highly area-efficient.
  • To analyze and compare the performance of the proposed S-box architecture against existing techniques.

Main Methods:

  • A novel S-box architecture was designed and conceptualized.
  • The architecture was evaluated for both CMOS and FPGA platforms.
  • A pipelined version of the S-box was developed to enhance throughput.
  • Performance analysis and comparative studies were conducted.

Main Results:

  • The proposed S-box architecture demonstrates ultra-low power consumption.
  • The design achieves robust parallelism and high efficiency in terms of area.
  • Pipelining further enhances time savings and throughput.
  • Comparative analysis confirms superior performance in power, delay, and size over existing methods.

Conclusions:

  • The novel S-box architecture offers significant improvements in AES performance metrics.
  • This design provides a highly efficient solution for low-power and high-speed cryptographic applications.
  • The architecture is suitable for both CMOS and FPGA implementations, offering flexibility.