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Genomic and Proteomic Characterization of Acute Kidney Injury

Prasad Devarajan1

  • 1Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Nephron
|October 23, 2015
PubMed

Insights

Acute kidney injury (AKI) is increasing worldwide. Genomics and proteomics offer new ways to find biomarkers and targets for better AKI prediction and treatment.

Area of Science:

  • Nephrology
  • Genomics
  • Proteomics

Background:

  • Global incidence and severity of acute kidney injury (AKI) are rising.
  • High morbidity and mortality persist despite therapeutic advances.
  • Incomplete understanding of pathophysiology, risk factors, and lack of early predictive biomarkers hinder progress.

Purpose of the Study:

  • To review current genomic and proteomic technologies.
  • To discuss their application in human AKI research.
  • To highlight emerging biomarkers and therapeutic targets.

Main Methods:

  • Review of current technologies in functional genomics: targeted sequencing, genome-wide association studies, transcriptome profiling.
  • Review of current technologies in proteomics: gel electrophoresis, mass spectrometry.
  • Application of these technologies to human AKI.

Main Results:

  • Genomics and proteomics are uncovering potential biomarkers for AKI.
  • These approaches are identifying novel therapeutic targets for AKI.
  • Advances in technology are improving the ability to study AKI.

Conclusions:

  • Genomic and proteomic technologies are crucial for advancing AKI research.
  • These 'omics' fields offer promise for early AKI prediction and novel therapeutics.
  • Further application of these technologies is essential to combat the rising AKI burden.

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