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    Rising carbapenemase-producing enterobacteriaceae (CPEs) require effective management. This London trust implemented increased screening and targeted reviews to efficiently detect and manage CPE cases, optimizing resource use.

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    Area of Science:

    • Infectious Diseases
    • Microbiology
    • Public Health

    Background:

    • Carbapenemase-producing Enterobacteriaceae (CPEs) present a growing global health threat.
    • Current management strategies, while guided by Public Health England, face implementation challenges due to cost.
    • Early detection and management of CPE colonization or infection are critical for effective control.

    Purpose of the Study:

    • To describe the development and implementation of a CPE management program in an acute London trust.
    • To improve the efficiency of CPE screening and resource allocation.
    • To identify key entry points for CPE within a hospital setting.

    Main Methods:

    • Initiated a trust-wide point-prevalence study to pinpoint CPE infection sources.
    • Implemented a program of increased screening for CPE.
    • Established a system for yearly reviews of CPE data and management strategies.

    Main Results:

    • The study identified specific points of CPE entry within the trust.
    • Increased screening allowed for more targeted interventions.
    • The program aims to optimize resource utilization for CPE management.

    Conclusions:

    • A proactive, targeted screening approach can enhance CPE management.
    • Efficient resource allocation is achievable through data-driven reviews and identified infection pathways.
    • This model offers a scalable solution for other healthcare settings facing rising CPE cases.