[A Case of Delayed-onset Multiple Metastatic Infection following Liver Abscess]

Kang Hoon Lee1, Sun Young Moon1, In Ae Kim1

  • 1Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Insights

Klebsiella pneumoniae liver abscess can spread to distant organs. This case highlights delayed, sequential metastatic infections following initial liver abscess treatment, emphasizing prolonged antibiotic therapy for full recovery.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Microbiology

Background:

  • Klebsiella pneumoniae liver abscess (KLA) is a significant clinical entity.
  • KLA has a known propensity for early and synchronous metastatic spread.

Observation:

  • A 59-year-old male presented with KLA, fever, and abdominal pain.
  • Initial treatment included percutaneous drainage and antibiotics, leading to symptom improvement.
  • Despite successful KLA management, the patient developed sequential, delayed metastatic infections including endophthalmitis, psoas abscess, and spondylitis.

Findings:

  • Metastatic infections occurred non-concurrently, appearing 5, 23, 30, and 65 days post-initial KLA diagnosis.
  • Each metastatic episode was treated with antibiotics, drainage, and surgery as indicated.
  • The patient achieved full recovery after extended intravenous antibiotic administration.

Implications:

  • This case underscores the potential for late-onset, sequential metastatic complications from K. pneumoniae liver abscess.
  • Aggressive and prolonged multimodal treatment is crucial for managing these disseminated infections.
  • Highlights the importance of vigilance for metastatic disease even after initial KLA treatment success.