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Murine Model of Metastatic Liver Tumors in the Setting of Ischemia Reperfusion Injury
Published on: August 30, 2019
[A Case of Delayed-onset Multiple Metastatic Infection following Liver Abscess]
Kang Hoon Lee1, Sun Young Moon1, In Ae Kim1
1Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.
Abstract:
Klebsiella pneumoniae liver abscess has a tendency to spread to distant sites early in the course of disease and to involve multiple organs synchronously. A 59-year-old male was admitted because of liver abscess accompanied by fever and abdominal pain. The patient underwent percutaneous catheter drainage and received intravenous antibiotics. Symptom relief was achieved after the treatment as well as marked reduction in the size of the abscess. Despite proper treatment of the liver abscess, however, patient developed multiple metastatic infections in a non-concurrent manner: left and right endophthalmitis, psoas abscess, and infectious spondylitis at 5, 23, 30 and 65 days after initial manifestations of liver abscess, respectively. Each infectious episode followed one another after resolution of the former one. For each episode of metastatic infections, the patient promptly underwent treatment with systemic and local antibiotics, interventional abscess drainage, and surgical treatments as needed. The patient fully recovered without sequelae after the use of intravenous antibiotics for an extended period of time. Herein, we report a case of K. pneumoniae liver abscess complicated with delayed-onset multiple metastatic infections.
Insights
Klebsiella pneumoniae liver abscess can spread to distant organs. This case highlights delayed, sequential metastatic infections following initial liver abscess treatment, emphasizing prolonged antibiotic therapy for full recovery.
Area of Science:
- Infectious Diseases
- Hepatology
- Microbiology
Background:
- Klebsiella pneumoniae liver abscess (KLA) is a significant clinical entity.
- KLA has a known propensity for early and synchronous metastatic spread.
Observation:
- A 59-year-old male presented with KLA, fever, and abdominal pain.
- Initial treatment included percutaneous drainage and antibiotics, leading to symptom improvement.
- Despite successful KLA management, the patient developed sequential, delayed metastatic infections including endophthalmitis, psoas abscess, and spondylitis.
Findings:
- Metastatic infections occurred non-concurrently, appearing 5, 23, 30, and 65 days post-initial KLA diagnosis.
- Each metastatic episode was treated with antibiotics, drainage, and surgery as indicated.
- The patient achieved full recovery after extended intravenous antibiotic administration.
Implications:
- This case underscores the potential for late-onset, sequential metastatic complications from K. pneumoniae liver abscess.
- Aggressive and prolonged multimodal treatment is crucial for managing these disseminated infections.
- Highlights the importance of vigilance for metastatic disease even after initial KLA treatment success.
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