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Related Experiment Video

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Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

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Silicone in the liver: possible late effects.

J Hunt¹, M J Farthing, L R Baker

¹Department of Gastroenterology, St Bartholomew's Hospital, London.

|February 1, 1989

Summary

Two kidney transplant patients developed liver abnormalities and scarring due to silicone particles. This suggests potential long-term liver complications from silicone degradation products in patients undergoing hemodialysis.

Area of Science:

Nephrology
Hepatology
Materials Science

Background:

Renal transplant recipients can develop various complications post-surgery.
Liver function abnormalities require thorough investigation to determine etiology.
Silicone materials are used in medical devices, including those for dialysis.

Observation:

Two renal transplant patients exhibited abnormal liver function tests and liver scarring.
Microscopic examination revealed silicone particles within the liver tissue of both patients.
Silicon presence was confirmed using x-ray energy dispersive spectroscopy.

Findings:

Chronic liver abnormalities were observed in patients even years after dialysis cessation and successful transplantation.
No alternative cause for the chronic liver disease was identified.

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The findings suggest a potential link between silicone degradation products and liver pathology.

Implications:

Silicone degradation products may represent an underrecognized cause of chronic liver disease in patients with a history of dialysis.
Patients utilizing siliconised peristaltic blood pump systems may be at risk for similar late-onset liver complications.
Further research is warranted to elucidate the mechanism of silicone-induced liver injury and identify at-risk populations.