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Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
Pseudomyxoma peritonei diagnosed 19 years after appendicectomy
Paula F Wrafter1, Tara Connelly2, Jody Sultan Ali Khan
1Department of Surgery, The Galway Clinic, Galway, Ireland.
Pseudomyxoma peritonei (PMP) is a rare condition of mucinous material accumulation in the abdomen. This case highlights a delayed diagnosis of PMP secondary to appendicitis, managed successfully with cytoreduction alone.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Pseudomyxoma peritonei (PMP) is characterized by intraperitoneal mucinous material accumulation.
- It can range from mucinous ascites to carcinomatosis, often originating from appendiceal tumors.
Observation:
- A 52-year-old woman presented with a 4-month history of abdominal pain and distension.
- She had a history of appendicectomy 19 years prior.
Findings:
- Radiological and pathological investigations confirmed PMP, likely secondary to a long-standing ruptured appendix.
- Diagnosis was significantly delayed due to the long interval since appendicectomy.
Implications:
- This case underscores the importance of considering PMP in patients with prolonged abdominal symptoms, even after appendicectomy.
- Management focused on surgical cytoreduction, demonstrating its potential efficacy in select PMP cases.
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