Related Experiment Video

Updated: Mar 31, 2026

Detection of microRNA Expression in Peritoneal Membrane of Rats Using Quantitative Real-time PCR
08:56

Detection of microRNA Expression in Peritoneal Membrane of Rats Using Quantitative Real-time PCR

Published on: June 27, 2017

8.4K

microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis

Melisa Lopez-Anton1, Timothy Bowen1, Robert H Jenkins1

  • 1Department of Nephrology, School of Medicine, College of Biomedical & Life Sciences, Cardiff University, Heath Park Campus, Cardiff CF14 4XN, UK.

Biomed Research International
|October 24, 2015
PubMed

Insights

MicroRNAs (miRNAs) play a crucial role in maintaining peritoneal dialysis (PD) function. Changes in miRNA expression in PD effluent cells contribute to PD failure by disrupting peritoneal homeostasis.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Genetics

Background:

  • Peritoneal dialysis (PD) relies on maintaining peritoneal cavity homeostasis and membrane function.
  • MicroRNAs (miRNAs) are key regulators of gene expression and cellular pathways.
  • Alterations in these pathways can lead to peritoneal membrane dysfunction and PD failure.

Purpose of the Study:

  • To review current findings on the role of miRNAs in peritoneal dialysis (PD) therapy.
  • To emphasize evidence of altered peritoneal miRNA expression during long-term PD.
  • To highlight the impact of these changes on peritoneal cavity homeostasis and PD outcomes.

Main Methods:

  • Literature-based review of published studies on miRNAs and PD.
  • Analysis of evidence for changes in miRNA expression in peritoneal dialysis effluent (PDE)-derived cells.
  • Emphasis on studies examining miRNA expression profiles during long-term PD treatment.

Main Results:

  • PD effluent-derived cells exhibit altered miRNA expression during PD therapy.
  • These miRNA expression changes contribute to the loss of peritoneal cavity homeostasis.
  • Altered miRNA profiles impact key molecular pathways regulating peritoneal cell homeostasis.

Conclusions:

  • Changes in miRNA expression are implicated in the progression of PD failure.
  • Further research into miRNA expression during PD is essential for understanding peritoneal cell homeostasis.
  • Investigating miRNA mechanisms offers a promising avenue for improving PD treatment and outcomes.

More Related Videos

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis07:11

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

16.2K
A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

3.4K

Related Concept Videos

Peritoneal Dialysis I: Introduction and Procedure01:30

Peritoneal Dialysis I: Introduction and Procedure

Peritoneal dialysis (PD) is a procedure that facilitates the exchange of solutes, waste products, electrolytes, and excess fluid between the blood in the peritoneal capillaries and a dialysis solution introduced into the peritoneal cavity.Principles of Peritoneal Dialysis (PD)Diffusion: Waste products such as urea and electrolytes move from high concentrations in the blood to low concentrations in the dialysate across the peritoneal membrane. This mechanism is driven by the concentration...
6.3K
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
1.4K
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications01:25

Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications

Peritoneal dialysis (PD) is a medical process that removes waste products and excess fluid from the body using the peritoneal membrane as a natural filter.Peritoneal Dialysis MethodsSeveral methods can be used for peritoneal dialysis, including Acute Intermittent Peritoneal Dialysis, Continuous Ambulatory Peritoneal Dialysis, and Automated Peritoneal Dialysis, also known as Continuous Cyclic Peritoneal Dialysis.Acute Intermittent Peritoneal Dialysis (AIPD) is used for patients with uremic...
1.6K
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
2.0K
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
2.2K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
479