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Related Concept Videos

Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Exocrine Glands: Methods of Secretion01:08

Exocrine Glands: Methods of Secretion

Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
Merocrine secretion is the most common type of exocrine secretion. The secretions are enclosed in vesicles and moved to the cell's apical surface, where the contents are released by exocytosis. For example, mucous, a watery secretion rich in the glycoprotein mucin, is a merocrine secretion. The eccrine glands...
Exocrine Glands: Types of Secretions01:13

Exocrine Glands: Types of Secretions

Exocrine glands produce and release a variety of glandular products. Exocrine glands can be classified into serous, mucous, or mixed types based on their secretory products.
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Salivary Glands and Saliva01:23

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
Regulation of Water Intake01:25

Regulation of Water Intake

Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...

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Related Experiment Video

Updated: Jul 26, 2026

Isolation of Mouse Salivary Gland Stem Cells
09:52

Isolation of Mouse Salivary Gland Stem Cells

Published on: February 8, 2011

Salivary gland fluid secretion during aging.

B J Baum1

  • 1Clinical Investigation and Patient Care Branch, National Institute of Dental Research, Bethesda, MD 20892.

Journal of the American Geriatrics Society
|May 1, 1989
PubMed
Summary

Salivary gland function remains good in healthy older adults and lab rats. However, disease or treatments can cause salivary disorders, which may be improved with medication for patients with remaining gland tissue.

Area of Science:

  • Gerontology
  • Oral Biology
  • Pharmacology

Background:

  • Salivary gland function is typically maintained in healthy elderly individuals.
  • Laboratory rat models show similar preservation of salivary gland function with aging.
  • Elderly populations exhibit increased susceptibility to salivary dysfunction from pathologies or medical interventions.

Purpose of the Study:

  • To investigate the impact of aging on salivary gland function.
  • To explore the potential for pharmacological interventions to restore salivary gland function in older individuals.

Main Methods:

  • Review of existing literature on aging and salivary gland physiology.
  • Analysis of data from laboratory rat studies on aging.
  • Evaluation of pharmacological approaches for salivary disorders.

More Related Videos

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
08:03

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

Published on: July 15, 2019

Protocol for Single-Cell Dissociation, RNA Sequencing, and Isolation of Myoepithelial Cells and Fibroblasts from the Aged Lacrimal and Salivary Glands
08:37

Protocol for Single-Cell Dissociation, RNA Sequencing, and Isolation of Myoepithelial Cells and Fibroblasts from the Aged Lacrimal and Salivary Glands

Published on: April 24, 2026

Related Experiment Videos

Last Updated: Jul 26, 2026

Isolation of Mouse Salivary Gland Stem Cells
09:52

Isolation of Mouse Salivary Gland Stem Cells

Published on: February 8, 2011

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
08:03

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers

Published on: July 15, 2019

Protocol for Single-Cell Dissociation, RNA Sequencing, and Isolation of Myoepithelial Cells and Fibroblasts from the Aged Lacrimal and Salivary Glands
08:37

Protocol for Single-Cell Dissociation, RNA Sequencing, and Isolation of Myoepithelial Cells and Fibroblasts from the Aged Lacrimal and Salivary Glands

Published on: April 24, 2026

Main Results:

  • Healthy aging generally preserves salivary gland function in humans and rats.
  • Disease and medical treatments significantly increase the risk of salivary disorders in older adults.
  • Pharmacological therapy shows promise for improving salivary function in patients with residual glandular tissue.

Conclusions:

  • While healthy aging maintains salivary function, older adults are at higher risk for salivary disorders.
  • Pharmacological treatments offer a viable strategy to improve salivary gland function in specific patient groups.