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Subclinical Thyroid Dysfunction and Frailty Among Older Men.

Vanessa S Virgini1, Nicolas Rodondi1, Peggy M Cawthon1

  • 1Department of Internal Medicine (V.S.V.), University Hospital of Zürich, 8091 Zürich, Switzerland; Department of General Internal Medicine (N.R.), Inselspital, University Hospital of Bern, 3010 Bern, Switzerland; California Pacific Medical Center Research Institute (L.H.), San Francisco, California 94107; Stanford University Medical School (A.R.H.), Palo Alto, California 94305; Bone and Mineral Unit (E.S.O.), Oregon Health & Science University, Portland, Oregon 97239; Department of Medicine (K.E.E.) and Division of Epidemiology and Community Health (K.E.E.), University of Minnesota, Minneapolis, Minnesota 55455; Center for Chronic Disease Outcomes Research (K.E.E.), Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota 55417; and Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94143.

The Journal of Clinical Endocrinology and Metabolism
|October 27, 2015
PubMed
Summary
This summary is machine-generated.

Subclinical hyperthyroidism is linked to prevalent frailty in older men, but not incident frailty. Subclinical hypothyroidism showed no consistent association with frailty in this study.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Geriatric Medicine

Background:

  • Subclinical thyroid dysfunction and frailty are common in older adults.
  • Existing data on their relationship is conflicting.

Purpose of the Study:

  • To examine cross-sectional and prospective associations between subclinical thyroid dysfunction and frailty.
  • To investigate the link between thyroid status and frailty subdomains: sarcopenia, weakness, slowness, exhaustion, and low activity.

Main Methods:

  • Prospective cohort study of 1455 men aged over 65.
  • Participants categorized by thyroid status: subclinical hyperthyroidism, subclinical hypothyroidism, and euthyroidism.
  • Frailty assessed using a modified Cardiovascular Health Study Index; associations analyzed cross-sectionally and prospectively over 5 years.

Main Results:

  • Subclinical hyperthyroidism was associated with increased odds of prevalent frailty at baseline (aOR 2.48), especially in men younger than 74.
  • No consistent association was found between baseline subclinical thyroid dysfunction (hypo- or hyperthyroidism) and incident frailty or frailty components after 5 years.

Conclusions:

  • Subclinical hyperthyroidism, not subclinical hypothyroidism, is associated with prevalent frailty in community-dwelling older men.
  • The association appears limited to prevalent frailty, not incident cases.