Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

11.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
11.0K
Channel Rhodopsins01:11

Channel Rhodopsins

3.4K
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
3.4K
The Retina01:32

The Retina

78.5K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
78.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transient infrared nanoscopy resolves the millisecond photoswitching dynamics of single lipid vesicles in water.

Nature communications·2025
Same author

Light-Activatable, Cell-Type Specific Labeling of the Nascent Proteome.

ACS chemical neuroscience·2024
Same author

A Photoactivated Protein Degrader for Optical Control of Synaptic Function.

bioRxiv : the preprint server for biology·2023
Same author

Magnetic hydrogel particles improve nanopore sequencing of SARS-CoV-2 and other respiratory viruses.

Scientific reports·2023
Same author

"I Like and Prefer to Work Alone": Social Anxiety, Academic Self-Efficacy, and Students' Perceptions of Active Learning.

CBE life sciences education·2021
Same author

Oral chronic graft-versus-host disease in Australia: clinical features and challenges in management.

Internal medicine journal·2015

Related Experiment Video

Updated: Mar 31, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.6K

Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist.

L Laprell1, K Hüll1, P Stawski1

  • 1Center of Integrated Protein Science Munich (CIPSM) at the Department of Chemistry Ludwig-Maximilians-Universität München , Munich 81377, Germany.

ACS Chemical Neuroscience
|October 27, 2015
PubMed
Summary

Researchers developed a new photopharmacology method using a photoswitchable amino acid (ATA) to restore vision. This approach selectively activates retinal cells in a light-dependent manner, offering an alternative to invasive treatments for degenerative eye diseases.

Keywords:
AMPA receptorsATAPhotopharmacologyphotochromic ligandretinal degeneration

More Related Videos

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro
12:56

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Published on: December 19, 2017

8.2K
Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
07:49

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Published on: September 17, 2014

12.0K

Related Experiment Videos

Last Updated: Mar 31, 2026

Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

4.6K
Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro
12:56

Methodology for Biomimetic Chemical Neuromodulation of Rat Retinas with the Neurotransmitter Glutamate In Vitro

Published on: December 19, 2017

8.2K
Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
07:49

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Published on: September 17, 2014

12.0K

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Pharmacology

Background:

  • Retinal degenerative diseases are challenging to treat and have diverse causes.
  • Current treatments often involve genetic manipulation or electronic implants.
  • Photopharmacology offers a promising, less invasive alternative for vision restoration.

Purpose of the Study:

  • To introduce a novel photopharmacological strategy for vision restoration.
  • To utilize a photoswitchable excitatory amino acid for targeted retinal cell activation.
  • To explore an alternative to existing invasive vision restoration therapies.

Main Methods:

  • Development of a photoswitchable excitatory amino acid, ATA.
  • Administration of ATA as a freely diffusible molecule.
  • Light-dependent activation of ATA to target specific retinal cells.

Main Results:

  • ATA selectively activates AMPA receptors in a light-dependent manner.
  • The primary targets of ATA are amacrine and retinal ganglion cells.
  • A minor effect on bipolar cells was also observed.

Conclusions:

  • This photopharmacological approach offers a new strategy for vision restoration.
  • ATA complements existing photopharmacological methods like photochromic channel blockers.
  • The findings enhance the potential of photopharmacology in treating degenerative retinal diseases.