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The association between serum ferritin levels and post-stroke depression.
Lin Zhu1, Bin Han1, Liping Wang1
1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Journal of Affective Disorders
|October 27, 2015
Summary
Elevated serum ferritin levels in stroke patients may predict the development of post-stroke depression (PSD). Higher ferritin levels at admission were significantly associated with PSD diagnosis two months later.
Area of Science:
- Neurology
- Psychiatry
- Biochemistry
Background:
- Post-stroke depression (PSD) is a common complication following stroke.
- Elevated serum ferritin levels have been linked to depression.
- The relationship between serum ferritin and PSD requires further investigation.
Purpose of the Study:
- To investigate the association between serum ferritin levels and the incidence of PSD.
- To determine if serum ferritin can predict the development of PSD in ischemic stroke patients.
Main Methods:
- 196 ischemic stroke patients were recruited within 24 hours of onset and followed for 2 months.
- Serum ferritin levels were measured at admission using electrochemiluminescence immunoassay.
- Depression was diagnosed using DSM-IV criteria and a HAMD-17 score of ≥ 7.
Main Results:
- 28.6% of stroke patients developed PSD at two months.
- Patients with PSD had significantly higher serum ferritin levels at admission compared to non-PSD patients and controls.
- Serum ferritin levels ≥ 130.15 µg/L were independently associated with PSD at two months (OR=5.388, P=0.004).
Conclusions:
- Elevated serum ferritin levels upon admission are associated with PSD.
- Serum ferritin may serve as a predictive biomarker for the development of post-stroke depression.
