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Modulators of the human ABCC2: hope from natural sources?

Elisabeta Baiceanu1,2, Gianina Crisan2, Felicia Loghin3

  • 1Drug Resistance Modulation & Membrane Proteins Laboratory, Molecular & Structural Basis of Infectious Systems, Mixed Research Unit between the National Centre for Scientific Research & Lyon I University n 5086, Institute of Biology & Chemistry of Proteins, 7 passage du Vercors 69367, Lyon, Cedex, France.

Future Medicinal Chemistry
|October 27, 2015
PubMed

Insights

Natural products show promise for modulating the human ATP-binding cassette transporter ABCC2 (ATP-binding cassette sub-family C member 2). These compounds may help overcome cancer multidrug resistance, particularly in ovarian cancer.

Area of Science:

  • Molecular Biology
  • Pharmacology
  • Biochemistry

Background:

  • Human ABCC2 (ATP-binding cassette sub-family C member 2) is a transporter protein crucial for exporting endogenous and exogenous substances.
  • ABCC2 plays a significant role in cisplatin resistance within cancer cells, with notable implications for ovarian cancer treatment.
  • Existing ABCC2 modulators exhibit limited efficacy, necessitating the discovery of novel and more effective compounds.

Purpose of the Study:

  • To explore natural products as a novel source for developing efficient ABCC2 modulators.
  • To review the fundamental aspects of ABCC2, including its distribution, structure, and physiological/pathological roles.
  • To summarize the impact of natural products on ABCC2 activity and their potential in cancer therapy.

Main Methods:

  • Literature review focusing on ABCC2 function and natural product interactions.
  • Analysis of plant metabolites reported to modulate ABCC2 activity.
  • Evaluation of natural products as potential agents against ABCC2-mediated multidrug resistance.

Main Results:

  • Natural products provide a diverse structural basis for developing new ABCC2 modulators.
  • Specific plant metabolites have demonstrated the ability to influence ABCC2 at various regulatory levels.
  • These natural compounds are identified as promising candidates for blocking ABCC2-driven multidrug resistance in cancer.

Conclusions:

  • Natural products represent a valuable and underexplored resource for discovering potent ABCC2 modulators.
  • Targeting ABCC2 with natural compounds offers a potential strategy to enhance the effectiveness of chemotherapy, especially in resistant cancers.
  • Further research into plant metabolites could lead to innovative therapeutic approaches for overcoming multidrug resistance.

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