Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aristolochic acid and the risk of female lung cancer: Population-based case-control study in Taiwan.

Cancer epidemiology·2026
Same author

Hydrolyzed chicken extract (ProBeptigen®) on sleep quality in healthy individuals: a secondary analysis of PSQI global and component scores from a randomized double-blind trial.

Frontiers in nutrition·2026
Same author

Reply to commentary on "Cogstate brief battery performance in assessing cognitive impairment in Taiwan: A prospective, multi-center study".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same author

Influence of interhospital transfer on endovascular thrombectomy outcome in acute ischemic stroke patients: an analysis of the TREAT-AIS registry.

Frontiers in neurology·2026
Same author

Digital reminiscence therapy in dementia care: a systematic review and meta-analysis.

BMC neurology·2026
Same author

Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Related Experiment Video

Updated: Mar 31, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.9K

BDNF Val66Met Polymorphism on Functional MRI During n-Back Working Memory Tasks.

Chih-Chung Chen1, Chi-Jen Chen, Dean Wu

  • 1From the Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei (CCC, HWC); Department of Neurology (CCC, DW, NFC, PCC, CJH); Department of Radiology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan (CJC, YPL); Human Brain Research Center, Kyoto University Graduate School of Medicine, Kyoto, Japan (YPL); Department of Neurology, Medical School, Taipei Medical University, Taipei (CJH); and Brain and Consciousness Research Center, Shuang Ho Hospital, New Taipei City, Taiwan (CJH).

Medicine
|October 27, 2015
PubMed
Summary

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences brain activity during working memory tasks. Met allele carriers show reduced activation in key brain regions compared to non-carriers.

More Related Videos

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies
10:09

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Published on: September 22, 2014

13.7K
Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients
09:42

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients

Published on: September 1, 2023

2.3K

Related Experiment Videos

Last Updated: Mar 31, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.9K
Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies
10:09

Transferring Cognitive Tasks Between Brain Imaging Modalities: Implications for Task Design and Results Interpretation in fMRI Studies

Published on: September 22, 2014

13.7K
Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients
09:42

Author Spotlight: Using Motor Imagery Brain-Computer Interface to Improve Motor and Cognitive Function in Stroke Patients

Published on: September 1, 2023

2.3K

Area of Science:

  • Neuroscience
  • Genetics
  • Cognitive Psychology

Background:

  • The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is linked to hippocampal issues and episodic memory deficits.
  • Its impact on working memory (WM) performance and associated brain activation patterns remains debated.

Purpose of the Study:

  • To investigate the effect of the BDNF Val66Met polymorphism on functional magnetic resonance imaging (fMRI) during n-back working memory tasks.
  • To examine brain activation patterns in healthy middle-aged adults with and without the Met allele.

Main Methods:

  • 110 healthy middle-aged adults without cognitive impairment underwent BDNF genotyping.
  • fMRI scans were performed during n-back working memory tasks on 11 Met allele carriers and 9 non-carriers.

Main Results:

  • Working memory performance was comparable between Met allele carriers and non-carriers.
  • Both groups showed increased brain activation with higher working memory loads.
  • Met allele carriers exhibited significantly lower activation in the right superior frontal gyrus and middle occipital gyrus compared to non-carriers (P < 0.001).

Conclusions:

  • The BDNF Val66Met polymorphism appears to modulate the working memory network.
  • Met allele carriers demonstrate reduced activation in specific frontal and occipital regions during WM tasks.
  • Potential mechanisms include altered WM network development during brain maturation.