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Published on: April 1, 2019
Tissue Factor Pathway Inhibitor-2 Gene Polymorphisms Associate With Coronary Atherosclerosis in Chinese Population
Jia Yu1, Rong-Le Liu, Xin-Ping Luo
1From the Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, 200040, China (JY, R-IL, X-PL, H-MS, J-JP, H-CN); and Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200032, China (DM).
Genetic variations in the Tissue Factor Pathway Inhibitor-2 (TFPI-2) gene are linked to coronary atherosclerosis in the Chinese population. While these TFPI-2 gene polymorphisms may help assess atherosclerosis risk, they did not strongly predict cardiovascular events.
Area of Science:
- Genetics
- Cardiovascular Disease
- Molecular Biology
Background:
- Atherosclerosis is a complex disease where Tissue Factor Pathway Inhibitor-2 (TFPI-2) may play a role.
- Understanding genetic factors influencing atherosclerosis is crucial for risk assessment.
Purpose of the Study:
- To investigate the association between TFPI-2 gene polymorphisms and coronary atherosclerosis.
- To evaluate if TFPI-2 gene variations predict cardiovascular events (CVEs).
Main Methods:
- Genotyping of nine single-nucleotide polymorphisms (SNPs) in the TFPI-2 gene using polymerase chain reaction-direct sequencing.
- Assessment of coronary atherosclerosis severity using the Gensini score.
- Follow-up for cardiovascular events over a median of 53 months.
Main Results:
- Two SNPs (rs59805398 and rs34489123) and five haplotypes of the TFPI-2 gene were significantly correlated with coronary atherosclerosis.
- No strong association was found between TFPI-2 gene polymorphisms and the occurrence of CVEs during follow-up.
Conclusions:
- TFPI-2 gene polymorphisms are associated with the presence of coronary atherosclerosis in the Chinese population.
- TFPI-2 gene polymorphisms may be useful for assessing the risk of developing coronary atherosclerosis.
- Current evidence is insufficient to support TFPI-2 gene polymorphisms as predictors of CVE occurrence.
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