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Updated: Mar 31, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Evidence of autochthonous hepatitis E in a Portuguese pediatric cohort, 1992-1995
J R Mesquita1, J Abreu-Silva2, J C Sousa3
1Polytechnic Institute of Viseu, Viseu, Portugal.
Abstract:
Despite the growing importance of hepatitis E virus (HEV) in industrialized countries, minimal attention has been given to autochthonous HEV infection in children. The present study screened archived sera (N = 71) from a Portuguese pediatric cohort collected in 1992-1995 for the presence of antibodies against HEV, using enzyme immunoassays and immunodot. Anti-HEV IgG was detected in two children and anti-HEV IgM in one, suggesting an acute HEV infection. This shows that HEV was circulating in the paediatric population of Portugal in the early 1990s.
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