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Published on: October 2, 2016
Curare Alkaloids: Constituents of a Matis Dart Poison
Gonzalo R Malca Garcia1, Lothar Hennig1, Irina V Shelukhina2
1Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig , Johannisallee 29, 04103 Leipzig, Germany.
Abstract:
A phytochemical study of dart and arrow poison from the Matis tribe led to the identification of D-(-)-quinic acid, L-malic acid, ethyldimethylamine, magnoflorine, and five new bisbenzyltetrahydroisoquinoline alkaloids (BBIQAs), 1-5. D-Tubocurarine could not be identified among these products. BBIQA (3) contains a unique linkage at C-8 and C-11'. All structures were characterized by a combination of NMR and HRESIMS data. The effects of Matis poison and individual BBIQAs (1-3) on rat muscle nAChR expressed in Xenopus oocytes have been investigated using the two-electrode voltage clamp technique.
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