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Updated: Mar 31, 2026
07:03
A Modified Co-Culture System for Understanding Granulosa-Theca Cell Interactions in the Bovine Ovary
Published on: September 19, 2025
729
Prohibitin( PHB) roles in granulosa cell physiology
Indrajit Chowdhury1, Kelwyn Thomas2, Winston E Thompson3,4
1Department of Obstetrics and Gynecology, Reproductive Science Research Program, Morehouse School of Medicine, 720 Westview Drive Southwest, Atlanta, GA 30310, USA. ichowdhury@msm.edu.
Cell and Tissue Research
|October 27, 2015
Summary
Prohibitin (PHB) is crucial for ovarian granulosa cell (GC) function in folliculogenesis. Further research is needed to fully understand PHB
Area of Science:
- Reproductive Biology
- Molecular Cell Biology
Background:
- Ovarian granulosa cells (GC) are vital for follicular development during folliculogenesis.
- Prohibitin (PHB) is a conserved protein found in various cellular compartments, including mitochondria and the nucleus.
Purpose of the Study:
- To review recent advancements in prohibitin (PHB) research concerning granulosa cell (GC) physiological functions.
- To highlight the known and unknown aspects of PHB regulation and its role in GC biology.
Main Methods:
- Literature review focusing on prohibitin (PHB) and ovarian granulosa cell (GC) research.
- Analysis of PHB's structure, cellular localization, and interactions within GC.
Main Results:
- PHB is involved in diverse cellular activities, including mitochondrial integrity, transcriptional regulation, and cell proliferation.
- PHB shuttles between mitochondria, cytosol, and nucleus, interacting with transcription factors and chromatin remodeling proteins.
Conclusions:
- PHB plays a significant role in GC physiology, impacting mitochondrial function and gene expression.
- The precise regulation of PHB and its complete functional role in granulosa cells require further investigation.
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