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Related Concept Videos

Mouse Models of Cancer Study02:43

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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Related Experiment Video

Updated: Mar 31, 2026

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
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Genetically-defined ovarian cancer mouse models.

Patrice J Morin1, Ashani T Weeraratna2

  • 1American Association for Cancer Research, Philadelphia, PA 19106, USA.

The Journal of Pathology
|October 27, 2015
PubMed
Summary

Epithelial ovarian cancer (EOC) is hard to detect and treat. This review examines genetically-defined mouse models for EOC, considering new theories on cancer origins to improve prevention and treatment strategies.

Keywords:
Fallopian tubeintraepithelial carcinomaovarian cancertransgenic mouse model

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Area of Science:

  • Oncology
  • Genetics
  • Gynecology

Background:

  • Epithelial ovarian cancer (EOC) presents significant challenges in early detection and effective treatment.
  • The etiology and molecular pathways of EOC development are not well understood.
  • Identifying precursor lesions and understanding EOC progression mechanisms remain difficult.

Purpose of the Study:

  • To review genetically-defined ovarian mouse models for epithelial ovarian cancer (EOC).
  • To evaluate existing EOC mouse models within the context of a new paradigm suggesting EOC may arise from various female genital tract tissues.
  • To discuss how this new paradigm can explain observed features in current EOC models.

Main Methods:

  • Review of existing literature on genetically-defined ovarian mouse models.
  • Analysis of these models in light of recent findings on EOC origins.
  • Discussion of the strengths and limitations of current models.

Main Results:

  • Genetically-defined mouse models are crucial tools for studying EOC.
  • A new paradigm suggests EOC may originate from tissues beyond the ovarian surface epithelium.
  • Re-evaluation of existing models is necessary to align with new understandings of EOC origins.

Conclusions:

  • Understanding the strengths and limitations of EOC mouse models is essential.
  • These models can be better utilized to elucidate EOC biology.
  • Improved models will aid in developing novel strategies for EOC prevention, detection, and treatment.