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Leptin signaling plays a critical role in the geniposide-induced decrease of tau phosphorylation.

Jianhui Liu1, Zixuan Liu2, Yonglan Zhang3

  • 1College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China Chongqing Key Lab of Catalysis & Functional Organic Molecules, Chongqing Technology and Business University, Chongqing 400067, China.

Acta Biochimica Et Biophysica Sinica
|October 27, 2015
PubMed
Summary
This summary is machine-generated.

Geniposide reduces tau phosphorylation, a key Alzheimer's disease marker, by enhancing leptin receptor signaling. This suggests geniposide

Keywords:
Alzheimer's diseaseGSK-3βgeniposideleptintau

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) plaques and tau hyperphosphorylation.
  • Geniposide previously showed efficacy in reducing Aβ production via leptin receptor signaling.
  • The effect of geniposide on tau phosphorylation and its mechanisms remain underexplored.

Purpose of the Study:

  • To investigate the effect of geniposide on tau phosphorylation.
  • To elucidate the role of leptin signaling in geniposide's effects on tau.
  • To explore geniposide as a potential therapeutic for Alzheimer's disease.

Main Methods:

  • Primary cultured cortical neurons and APP/PS1 transgenic mice were used.
  • Geniposide treatment and leptin antagonist (LA) administration were performed.
  • Leptin receptor expression, tau phosphorylation, Akt, and GSK-3β phosphorylation were assessed.

Main Results:

  • Geniposide up-regulated leptin receptor expression and decreased tau phosphorylation.
  • Leptin antagonist (LA) blocked geniposide's effects on tau phosphorylation.
  • LA also inhibited geniposide-induced phosphorylation of Akt and GSK-3β.

Conclusions:

  • Geniposide regulates tau phosphorylation through leptin signaling.
  • Geniposide demonstrates potential as a therapeutic agent for Alzheimer's disease.