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Updated: Mar 31, 2026
Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Bilateral uveal melanomas with different gene expression detected with 7 years interval
Nils Eide1, Øystein Garred2, Klaus Beiske2
1Eye Department, Oslo University Hospital HF, Oslo, Norway.
Purpose:
To report a bilateral uveal melanoma detected in a micrometastasis study.
Method:
Case report.
Results:
At enucleation of a circumpapillary amelanotic mixed melanoma in a patient with ocular melanocytosis, a pigmented lesion in the other eye was detected, thought to be a naevus. BAP1 was positive showing nuclear staining of the tumour cells. Seven years later the naevus showed growth and development of a retinal detachment. FNAB disclosed monosomy 3 in the spindle tumour cells.
Conclusion:
A case of bilateral melanoma with long-term survival without metastatic diseases is reported. Different gene expressions in the two eyes were revealed. The case is a reminder that follow-up over years is essential in patients with a uveal melanoma, especially with ocular melanocytosis.
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