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Hepatitis C virus genotypes in Kenya.
Joseph Mwangi1,2, Zipporah Nganga3, Solomon Mpoke4
1Center for Virus Research, Kenya Medical Research Institute, P.O. Box 54628, Nairobi, Kenya. mwangijose@yahoo.com.
Archives of Virology
|October 27, 2015
Summary
Hepatitis C virus (HCV) genotypes in Kenya were identified, revealing genotype 2b as dominant (90%) in blood donors. This study provides crucial data on HCV prevalence and types in Kenya.
Area of Science:
- Virology
- Public Health
- Genetics
Background:
- Hepatitis C virus (HCV) poses a significant global health challenge.
- Phylogenetic analysis has classified HCV into six main genotypes with numerous subtypes.
- Limited data exists on HCV seroprevalence and genotypes within Kenya.
Purpose of the Study:
- To determine the circulating Hepatitis C virus genotypes in the Kenyan blood donor population.
- To contribute essential epidemiological data on HCV in a region with scarce information.
Main Methods:
- Blood donor samples were initially screened for HCV antibodies.
- Seropositive samples were confirmed using polymerase chain reaction (PCR).
- Positive samples underwent sequencing and phylogenetic analysis to identify HCV genotypes.
Main Results:
- Out of 100 samples, 16 were initially seropositive, with only 10 confirmed as viremic by PCR (10% overall).
- The majority of viremic samples were from females (60%) with a mean age of 25 years.
- Genotypic analysis revealed genotype 1a (10%) and a predominant genotype 2b (90%).
Conclusions:
- This study identifies genotype 2b as the most prevalent HCV type among Kenyan blood donors.
- The findings highlight the need for further research into HCV epidemiology in Kenya.
- Understanding HCV genotypes is vital for effective public health strategies and treatment.
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