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Pediatric reference values for serum creatinine and estimated glomerular filtration rate in Iranians: Tehran Lipid
Asghar Ghasemi1, Iraj Azimzadeh2, Marjan Afghan1
1Endocrine Physiology Research Center, Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
This study establishes pediatric reference values for serum creatinine and estimated glomerular filtration rate (eGFR) in Iranian children. These findings provide crucial benchmarks for diagnosing kidney function in pediatric populations.
Area of Science:
- Pediatric Nephrology
- Clinical Chemistry
- Biomarkers
Background:
- Serum creatinine is a primary biomarker for estimating glomerular filtration rate (GFR).
- Establishing accurate pediatric reference values for serum creatinine and eGFR is essential for clinical practice.
Purpose of the Study:
- To determine pediatric reference values for serum creatinine and estimated GFR (eGFR).
- To utilize data from a population-based study in Iran for establishing these values.
Main Methods:
- Serum creatinine was measured in 1594 Iranian children (aged 3-18 years) using the Jaffe method.
- Estimated GFR (eGFR) was calculated using Schwartz and Counahan-Barratt equations.
- Reference values were determined following CLSI/IFCC guidelines.
Main Results:
- Serum creatinine levels significantly increased with age in both boys and girls.
- Boys exhibited higher mean serum creatinine concentrations compared to girls.
- A novel formula was proposed for estimating serum creatinine based on age and gender.
Conclusions:
- Pediatric reference ranges for serum creatinine were established: 0.6-1.20 mg/dL for boys and 0.6-1.00 mg/dL for girls.
- Pediatric reference ranges for eGFR were established: 81-154 mL/min/1.73 m² for boys and 80-129 mL/min/1.73 m² for girls.
- These established values are valuable for diagnostic and therapeutic decisions in pediatric care.
Background:
Serum creatinine is the most widely used marker for estimating glomerular filtration rate (GFR). The aim of this study was to determine pediatric reference values for serum creatinine levels and eGFR values using data from a population-based study in Iran.
Methods:
Serum creatinine of 1594 subjects, aged 3 - 18 years, participating in phase 4 of the Tehran Lipid and Glucose Study (2008 - 2011) was measured using the conventional Jaffe method. The non-parametric method of Schwartz and Counahan-Barratt equations were used to calculate eGFR. CLSI/IFCC guidelines were used to determine reference values.
Results:
In both genders, serum creatinine concentration was significantly increased with age and had a positive correlation with age (boys (r = 0.786, n = 778, P < 0.001) and girls (r = 0.638, n = 724, P < 0.001)). In addition, mean serum creatinine concentration was significantly higher in boys, compared to girls (0.86 ± 0.01 vs. 0.80 ± 0.01 mg/dL, P < 0.001). Based on these results, we proposed the following formula: serum creatinine (mg/dL) = k × age (year) + 0.5, where k was 0.03 for boys and 0.02 for girls.
Conclusions:
This study presents pediatric reference values in Iranian boys and girls for serum creatinine levels to be 0.6 - 1.20 mg/dL and 0.6 - 1.00 mg/dL and for eGFR values to be 81 - 154 mL/min/1.73 m(2) and 80 - 129 mL/min/1.73 m(2), respectively. These values can be used for diagnostic and therapeutic purposes.