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Risk factors of outcomes in elderly patients with acute ischemic stroke in China
Qi Wu1, Chunying Zou2, Chengji Wu3
1Department of Neurology, Tongji University School of Medicine Yangpu Hospital, Shanghai, 200090, China.
Insights
Stroke significantly impacts elderly patients, with subtype and severity affecting outcomes like mortality and dependency. Understanding these factors is crucial for reducing stroke burden in older populations.
Area of Science:
- Geriatric medicine
- Neurology
- Public health
Background:
- Stroke outcomes are poor in elderly patients, but factors influencing these outcomes over time remain unclear.
- This study addresses the knowledge gap regarding long-term stroke outcomes and associated risk factors in the elderly population.
Purpose of the Study:
- To evaluate the outcomes of stroke in elderly patients (aged ≥80 years) at 3 and 12 months post-stroke.
- To identify risk factors associated with mortality, dependency (modified Rankin Scale >2), and recurrence in this demographic.
Main Methods:
- A cohort of 419 acute ischemic stroke patients aged ≥80 years was assessed at 3 months, with 309 followed up at 12 months.
- Outcomes including mortality, dependency, and recurrence rates were recorded.
- Multivariate analysis was used to identify independent risk factors, adjusting for confounding variables.
Main Results:
- At 12 months, mortality and dependency rates were 26.9% and 58.0%, respectively. Recurrence rates increased from 18.1% at 3 months to 32.6% at 12 months.
- Stroke severity and TOAST classification were associated with mortality and recurrence.
- Stroke severity was a significant predictor of dependency at both 3 and 12 months.
Conclusions:
- Stroke subtype and severity are key determinants of stroke outcomes in elderly patients.
- These findings underscore the importance of identifying and managing factors affecting stroke outcomes to mitigate the impact of stroke on the elderly population in China.
Background:
Stroke results in poor outcomes among elderly patients. However, the factors associated with outcome over different follow-up periods in this population are unknown.
Aims:
To evaluate the outcomes and risk factors of outcomes in elderly patients after stroke.
Materials And Methods:
Outcomes, including mortality, dependency (defined as a mRS >2), and recurrence rates, and associated risk factors were assessed at 3 and 12 months after stroke in patients aged ≥80 years.
Results:
There were 419 acute ischemic stroke patients aged ≥80 years at 3 months, and 309 patients at 12 months; outcomes and relevant risk factors were assessed in these patients. Hypertension was more prevalent in women than in men. At 3 months, the mortality, dependency, and recurrence rates were 13.8, 54.2, and 18.1 %, respectively; the corresponding rates at 12 months were 26.9, 58.0, and 32.6 %, respectively. In the multivariate analysis, after adjusting by confounding factors, TOAST classification and stroke severity were associated with mortality and recurrence, while stroke severity was associated with dependency at 3 months. The mortality and dependency rates at 12 months were significantly associated with moderate and severe stroke, but severe stroke was an independent factor associated with recurrence.
Conclusion:
Stroke subtype and severity were associated with stroke outcomes among elderly patients in northern China. These findings suggest that it is crucial to highlight the affected factors of stroke outcome among elderly patients for reduce the burden of stroke in China.
