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Retinal and optic nerve changes in glaucoma: From animal study to clinical implication.
Shenton S L Chew1, Alessandra Martins2, Nicholas Strouthidis3
1NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
Progress in Brain Research
|October 27, 2015
Summary
Animal models enable tracking of optic nerve head and retinal nerve fiber layer changes in glaucoma. Advanced imaging techniques and algorithms are key for monitoring disease progression.
Area of Science:
- Ophthalmology
- Neuroscience
- Biomedical Imaging
Background:
- Experimental glaucoma models allow for detailed longitudinal studies.
- Optic nerve head (ONH) and retinal nerve fiber layer (RNFL) are critical targets in glaucoma.
- Histomorphometric analysis provides a gold standard for comparison.
Purpose of the Study:
- To investigate the utility of advanced imaging in characterizing glaucoma-induced structural changes.
- To evaluate the potential of these methods for monitoring glaucoma progression.
Main Methods:
- Utilizing confocal scanning laser tomography (CSLT) for ONH surface analysis.
- Employing spectral domain optical coherence tomography (SD-OCT) for deep structure imaging.
- Correlating imaging findings with histomorphometric data.
Main Results:
- CSLT and SD-OCT can detect early structural alterations in experimental glaucoma.
- Imaging modalities provide longitudinal data on ONH and RNFL changes.
- These methods show promise in complementing histomorphometric assessments.
Conclusions:
- Animal models are valuable for studying glaucoma pathogenesis and structural changes.
- Advanced imaging techniques like CSLT and SD-OCT are crucial for early glaucoma detection.
- Algorithms integrating imaging parameters and RNFL measurements will advance glaucoma progression monitoring.
