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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Related Experiment Video

Updated: Mar 31, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Celiac Disease: Background and Historical Context.

Graham D Turner1,2, Margaret R Dunne3,4,5, Anthony W Ryan6,7

  • 1Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.

Methods in Molecular Biology (Clifton, N.J.)
|October 27, 2015
PubMed
Summary
This summary is machine-generated.

Celiac disease, an autoimmune disorder triggered by gluten, has a long history. Modern research, including genomics, is advancing our understanding of its causes and prevalence.

Keywords:
Celiac diseaseGenetic riskGlutenHLAT cellTransglutaminase

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Area of Science:

  • Immunology
  • Genetics
  • Gastroenterology

Background:

  • Celiac disease descriptions date to antiquity, with modern understanding evolving significantly in the 20th century.
  • Key factors identified include the dietary trigger (gluten), major genetic determinants, and the specific autoantigen.
  • Epidemiological insights into age of onset and prevalence, including subclinical cases, have also been established.

Observation:

  • Genomic advances have identified loci contributing over 50% of the genetic risk for celiac disease.
  • High-throughput analyses in genomics, biochemistry, and cell biology are generating vast datasets.
  • Bioinformatics tools are crucial for interpreting this complex data.

Findings:

  • This primer synthesizes historical, epidemiological, immunological, molecular, and genetic perspectives on celiac disease.
  • It highlights the critical requirements for celiac disease research, including subject identification and sample collection.
  • Established genetic loci explain a significant portion of inherited predisposition.

Implications:

  • Continued research utilizing advanced analytical techniques and bioinformatics promises deeper insights into celiac disease.
  • A comprehensive understanding is essential for improved diagnostics and therapeutic strategies.
  • Future prospects for celiac disease research are promising, building on current knowledge and technological advancements.