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Updated: Mar 31, 2026

Laser-induced Breakdown Spectroscopy: A New Approach for Nanoparticle's Mapping and Quantification in Organ Tissue
Published on: June 18, 2014
In-situ characterization of nanoparticle beams focused with an aerodynamic lens by Laser-Induced Breakdown Detection
F-A Barreda1,2, C Nicolas2, J-B Sirven3
1CEA, DSM/IRAMIS/NIMBE-UMR 3685, F-91191 Gif-sur-Yvette, France.
Abstract:
The Laser-Induced Breakdown Detection technique (LIBD) was adapted to achieve fast in-situ characterization of nanoparticle beams focused under vacuum by an aerodynamic lens. The method employs a tightly focused, 21 μm, scanning laser microprobe which generates a local plasma induced by the laser interaction with a single particle. A counting mode optical detection allows the achievement of 2D mappings of the nanoparticle beams with a reduced analysis time thanks to the use of a high repetition rate infrared pulsed laser. As an example, the results obtained with Tryptophan nanoparticles are presented and the advantages of this method over existing ones are discussed.
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