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Magnetic Resonance-Guided Drug Delivery
Andrew S Mikhail1, Ari Partanen2, Pavel Yarmolenko3
1Center for Interventional Oncology, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
Magnetic Resonance Imaging Clinics of North America
|October 27, 2015
Summary
Image-guided drug delivery (IGDD) uses clinical imaging for enhanced antitumor efficacy. Magnetic resonance imaging (MRI) offers high resolution for planning and personalizing drug treatments.
Area of Science:
- Biomedical Engineering
- Radiology
- Oncology
Background:
- Image-guided drug delivery (IGDD) is a promising strategy to improve cancer treatment efficacy.
- Magnetic resonance (MR) imaging is well-suited for IGDD due to its high spatiotemporal resolution and quantitative capabilities.
- IGDD aims to enhance treatment outcomes through improved planning, real-time guidance, and personalized pharmacologic interventions.
Purpose of the Study:
- To review the fundamental principles of targeted drug delivery.
- To highlight the current applications and emerging uses of MR-guided drug delivery.
- To discuss future directions and paradigms in MR-guided drug delivery.
Main Methods:
- Review of existing literature on targeted drug delivery systems.
- Analysis of the role of MR imaging in guiding drug delivery.
- Synthesis of current and future applications of MR-guided drug delivery.
Main Results:
- MR imaging provides high-resolution data crucial for precise drug delivery.
- IGDD strategies enable real-time monitoring and adjustment of treatment.
- The integration of MR imaging enhances the planning and personalization of cancer therapies.
Conclusions:
- MR-guided drug delivery represents a significant advancement in oncology.
- Further research into emerging applications will expand the potential of IGDD.
- Personalized pharmacologic interventions guided by MR imaging hold promise for improved patient outcomes.
Keywords:
CancerDrug deliveryHigh-intensity focused ultrasoundImaging guidanceMR imagingNanomedicineThermosensitive liposomeTumor targetingMore Related Videos
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