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Cerebral venous thrombosis: comparing characteristics of infective and non-infective aetiologies: a 12-year

Pat Korathanakhun1, Wongchan Petpichetchian2, Pornchai Sathirapanya1

  • 1Faculty of Medicine, Department of Internal Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Postgraduate Medical Journal
|October 27, 2015
PubMed

Insights

Infection-associated cerebral venous thrombosis (IACVT) presents differently than non-infective CVT (NIACVT). IACVT often involves cavernous sinus thrombosis and male gender, while NIACVT typically features focal neurological deficits.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • Cerebral venous thrombosis (CVT) is often non-infective, but infection-associated CVT (IACVT) can be catastrophic.
  • Distinguishing IACVT from non-infection-associated CVT (NIACVT) is crucial for timely diagnosis and management.

Purpose of the Study:

  • To compare the clinical characteristics, neuroimaging findings, and outcomes of IACVT and NIACVT.

Main Methods:

  • Retrospective analysis of CVT patients (2002-2013) at Songklanagarind Hospital.
  • Comparison of clinical presentations, neuroimaging, and outcomes between IACVT and NIACVT groups.
  • Detailed analysis of infection sources, immune status, and microbiology in IACVT patients.

Main Results:

  • IACVT accounted for 24.1% of CVT cases.
  • IACVT was more common in males and those with diabetes, often presenting as cavernous sinus thrombosis.
  • NIACVT more frequently presented with focal neurological syndrome.
  • Paracranial infections (sinusitis, orbital cellulitis) were primary sources in 80% of IACVT cases.
  • Fungal infections in IACVT were associated with high rates of intracranial complications.

Conclusions:

  • Cavernous sinus thrombosis is a key indicator of IACVT.
  • Focal neurological syndrome suggests NIACVT.
  • Paracranial fungal infections pose a significant threat in IACVT, leading to severe intracranial complications.
Abstract

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