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Related Experiment Videos

Polymicrobial bacteremia: clinical and microbiologic patterns.

A G Reuben1, D M Musher, R J Hamill

  • 1Department of Medicine, Houston Veterans Administration Medical Center, Texas 77030.

Reviews of Infectious Diseases
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Polymicrobial bacteremia (PMB) in severe illness often originates from intraabdominal or urinary sources. Specific bacterial combinations can help predict infection origin, with a 21% mortality rate observed.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Polymicrobial bacteremia (PMB) presents diagnostic and therapeutic challenges.
  • Understanding PMB sources and outcomes is crucial for patient management.

Purpose of the Study:

  • To analyze the sources, causative organisms, and outcomes of PMB.
  • To identify predictors for PMB source and clinical presentation.

Main Methods:

  • Retrospective review of 97 patients with PMB treated by an infectious disease service from 1971-1987.
  • Analysis of patient demographics, underlying illnesses, infection sources, and microbial isolates.
  • Correlation of bacterial species combinations with infection sources.

Main Results:

  • Most patients (74/97) had severe underlying illnesses, and 80% of infections were hospital-acquired.

Related Experiment Videos

  • Common sources included intraabdominal (45 patients), urinary tract, and soft tissue infections.
  • Escherichia coli and Klebsiella species were frequent gram-negative isolates; Streptococcus faecalis and Staphylococcus aureus predominated gram-positive isolates.
  • Specific combinations like S. aureus with gram-negative rods suggested skin/soft tissue sources, while S. faecalis with gram-negative bacilli indicated intraabdominal origins.
  • Mortality was 21%, lower than previously reported for PMB.

    • Conclusions:

    • PMB in severely ill patients frequently arises from intraabdominal and urinary sources.
    • Certain bacterial combinations can aid in identifying the PMB source.
    • The observed mortality rate for PMB is comparable to that of monomicrobial bacteremia.