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Potassium Channel Blockade Enhances Atrial Fibrillation-Selective Antiarrhythmic Effects of Optimized State-Dependent

Martin Aguilar1, Feng Xiong1, Xiao Yan Qi1

  • 1From the Research Center, Montreal Heart Institute and Université de Montréal, Montreal, QC, Canada (M.A., F.X., X.Y.Q., P.C., S.N.); Department of Molecular and Integrative Physiology/Institute of Biomedical Engineering (M.A., P.C.) and Department of Medicine (S.N.), Université de Montréal, Montreal, QC, Canada; and Departments of Medicine (M.A., S.N.) and Pharmacology and Therapeutics (F.X., S.N.), McGill University, Montreal, QC, Canada; and West-German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Essen, Germany (S.N.).

Circulation
|October 27, 2015
PubMed
Summary

Adding potassium (K(+)) channel blockers to sodium (Na(+)) channel blockers enhances atrial fibrillation (AF) rhythm control. This combination therapy shows improved atrial selectivity and efficacy in terminating AF, offering a promising antiarrhythmic drug strategy.

Keywords:
anti-arrhythmia agentsatrial fibrillation

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