Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Markers of tubular dysfunction.

M Piscator1

  • 1Department of Environmental Hygiene, Karolinska Institute, Stockholm, Sweden.

Toxicology Letters
|March 1, 1989
PubMed
Summary

Accurate detection of low-molecular-weight proteins aids in identifying early proximal tubule damage. While total protein screening is economical, specific biomarkers like enzymes offer more detailed insights into nephrotoxic effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early detection of tubular dysfunction.

Kidney international. Supplement·1991
Same author

Assessment of variability in individual exposure to metals.

International archives of occupational and environmental health·1988
Same author

Dietary exposure to cadmium and health effects: impact of environmental changes.

Environmental health perspectives·1985
Same author

Long-term observations on tubular and glomerular function in cadmium-exposed persons.

Environmental health perspectives·1984
Same author

Metallothionein in rabbit kidneys preserved for transplantation.

Environmental health perspectives·1984
Same author

Cadmium in blood and urine related to present and past exposure. A study of workers in an alkaline battery factory.

British journal of industrial medicine·1983

Area of Science:

  • Nephrology
  • Biochemistry
  • Toxicology

Background:

  • Tubular proteinuria was first described in 1958.
  • Advances in diagnostics now allow for precise detection of subtle proximal tubule dysfunction.
  • Early identification of kidney tubule damage is crucial for timely intervention.

Purpose of the Study:

  • To review the diagnostic advancements for detecting proximal tubule dysfunction.
  • To evaluate the utility of various biomarkers for assessing tubular damage.
  • To highlight the potential of specific protein markers in nephrotoxicity studies.

Main Methods:

  • Review of diagnostic methods for tubular proteinuria.
  • Analysis of low-molecular-weight protein excretion.
  • Assessment of total protein, glucose, phosphate, and amino acid determinations.
  • Evaluation of high-molecular-weight enzymes as indicators of tubular cell damage.

Main Results:

  • Small increases in low-molecular-weight protein excretion can be accurately measured.
  • Total protein determination is a cost-effective screening tool but lacks specificity.
  • Glucose, phosphate, and amino acid levels are influenced by diet, limiting their diagnostic sensitivity.
  • High-molecular-weight enzymes show promise for studying acute and chronic nephrotoxic effects, though further research is needed.

Conclusions:

  • Modern diagnostics enable precise measurement of early proximal tubule dysfunction via low-molecular-weight proteins.
  • While total protein screening is useful, specific biomarkers are necessary for detailed damage assessment.
  • High-molecular-weight enzymes represent a valuable area for future research in nephrotoxicity evaluation.

Related Experiment Videos