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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

101.0K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
101.0K
DNA Microarrays02:34

DNA Microarrays

23.0K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Related Experiment Video

Updated: Mar 31, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Standardization efforts enabling next-generation sequencing and microarray based biomarkers for precision medicine.

Yuanting Zheng1, Tao Qing1, Yunjie Song1

  • 1Center for Pharmacogenomics & Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, China.

Biomarkers in Medicine
|October 27, 2015
PubMed
Summary

Standardizing microarray and sequencing technologies is crucial for clinical biomarker tests. Community efforts like the MAQC/SEQC project developed standards and best practices for reliable genomic data in precision medicine.

Keywords:
MAQCSEQCbiomarkergenomicsmicroarraynext-generation sequencingphenomicsprecision medicine

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Area of Science:

  • Biomedical research
  • Genomics
  • Translational science

Background:

  • Microarrays and next-generation sequencing (NGS) are vital in biomedical research.
  • Ensuring analytical validity is essential for their use as clinical biomarker tests.
  • Standardization and quality control are needed to improve reliability.

Purpose of the Study:

  • To review community-wide efforts in standardizing genomic technologies.
  • To highlight the development of consensus-based standards and best practices.
  • To establish a foundation for the translational application of genomics in precision medicine.

Main Methods:

  • Review of community-wide standardization projects, including the MicroArray and Sequencing Quality Control (MAQC/SEQC) project.
  • Identification of factors influencing microarray and sequencing technology performance.
  • Development of consensus-based standards and best practices.

Main Results:

  • Key factors influencing microarray and sequencing performance were identified.
  • Consensus-based standards and best practices were established.
  • Reference materials and datasets were created for evaluating technical proficiency.

Conclusions:

  • Standardization efforts have significantly improved the quality of genomic research.
  • Established standards and best practices provide a foundation for clinical applications.
  • These advancements pave the way for realizing precision medicine through genomics.